Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity
نویسندگان
چکیده
منابع مشابه
Regulation of Nitric Oxide by Cigarette Smoke in Airway Cells
Background and Objectives: Exhaled nitric oxide (NO) is decreased by smoking while oxides of nitrogen such as nitrites/nitrates (NOx) are increased. It was hypothesised that in vitro cigarette smoke extract (CSE) would either inhibit NO generation by increasing the NO synthase inhibitor, NG, NG-dimethyl-L-arginine (ADMA) or increase NOx levels via an oxidation pathway, which in turn could be in...
متن کاملCigarette Smoke Upregulates Rat Coronary Artery Endothelin Receptors In Vivo
BACKGROUND Cigarette smoking is a strong cardiovascular risk factor and endothelin (ET) receptors are related to coronary artery diseases. The present study established an in vivo secondhand smoke (SHS) exposure model and investigated the hypothesis that cigarette smoke induces ET receptor upregulation in rat coronary arteries and its possible underlying mechanisms. METHODOLOGY/PRINCIPAL FIND...
متن کاملRegulation of Cigarette Smoke (CS)-Induced Autophagy by Nrf2
Cigarette smoke (CS) has been reported to induce autophagy in airway epithelial cells. The subsequent autophagic cell death has been proposed to play an important pathogenic role in chronic obstructive pulmonary disease (COPD); however, the underlying molecular mechanism is not entirely clear. Using CS extract (CSE) as a surrogate for CS, we found that it markedly increased the expressions of b...
متن کاملChanges of brain endothelin levels and peripheral endothelin receptors by chronic cigarette smoke in spontaneously hypertensive rats.
The present study was conducted to evaluate the contribution of endothelin (ET) to the pharmacodynamic response to chronic cigarette smoke in spontaneously hypertensive rats (SHR). The contribution of ET was studied consequent to the hemodynamic response following 8 weeks of cigarette smoke by determining the changes in tissue ET-1 content and ET receptors. The blood pressure (BP) at the early ...
متن کاملTwo-dimensional Simulation of Mass Transfer and Nano-Particle Deposition of Cigarette Smoke in a Human Airway
The chance of developing lung cancer is increased through being exposed to cigarette smoke illustrated by studies. It is vital to understand the development of particular histologic-type cancers regarding the deposition of carcinogenic particles, which are present in human airway. In this paper, the mass transfer and deposition of cigarette smoke, inside the human airway, are investigated apply...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2010
ISSN: 1537-744X
DOI: 10.1100/tsw.2010.204